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Testosterone regulation of sex steroid-related mRNAs and dopamine-related mRNAs in adolescent male rat substantia nigra

Tertia D Purves-Tyson123, David J Handelsman4, Kay L Double23, Samantha J Owens123, Sonia Bustamante5 and Cynthia Shannon Weickert126*

Author Affiliations

1 Schizophrenia Research Institute, Sydney 2021, Australia

2 Neuroscience Research Australia, Sydney 2031, Australia

3 School of Medical Sciences, University of New South Wales, Sydney 2031, Australia

4 ANZAC Research Institute, Concord, 2139, Australia

5 Bioanalytical Mass Spectroscopy Facility, University of New South Wales, Sydney 2031, Australia

6 School of Psychiatry, University of New South Wales, Sydney 2031, Australia

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BMC Neuroscience 2012, 13:95  doi:10.1186/1471-2202-13-95

Published: 6 August 2012

Additional files

Additional file 1:

Comparison of LC-MS/MS and GC-MS measurements of circulating testosterone and DHT in rat sera. Circulating androgens were measured in sera using two mass spectroscopy methods, GC-MS and LC-MS/MS. Correlations of testosterone and DHT levels measured by the two methods were performed. Testosterone levels measured by GC-MS and LC-MS/MS correlated (r=0.86, p < 0.0001).

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