Table 1

Effect of kainic acid administration on seizure parameters in normoglycemic, hypoglycemic and hyperglycemic mice
Mouse strain Glycemic status Stages 1-4 (% of mice) Stage 5 (% of mice) Latency (min) Duration (min)
FVB/NJ Normoglycemic 100 96.37 32.8 ± 1.6 69.6 ± 4.7
C57BL/6 Normoglycemic 100 93.76 30.5 ± 1.3 76.3 ± 2.8
C57BL/6 Hypoglycemic 100 89.34 30.4 ± 6.4 55.4 ± 14.4
C57BL/6 Non-ketotic hyperglycemic 100 92.58 49.6 ± 6.1a 66.2 ± 4.0
C57BL/6 STZ-hyperglycemic 100 96.08 36.5 ± 4.6 93.3 ± 2.9b

KA induced a similar level of stage, latency and seizure duration irrespective of mouse strain. A significant difference in latency to onset of stage 4 seizures was observed in non-ketotic hyperglycemic mice as compared to normoglycemic C57BL/6 mice (aF=7.50; P=0.03) and a significant difference in duration of stage 4/5 seizures was observed in STZ-hyperglycemic mice as compared to normoglycemic C57BL/6 mice (bF=17.56; P=0.006).

Schauwecker

Schauwecker BMC Neuroscience 2012 13:94   doi:10.1186/1471-2202-13-94

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