Table 1

Summary of IPA Ingenuity analysis for the upper, middle, and deep cortical zones
IPA Ingenuity Pathway Analysis 317 GENES (ALL)
Diseases and Disorders p-value #genes
Neurological Disease 2.40E-21 - 1.99E-02 164
Psychological Disorder 3.15E-16 - 1.99E-02 85
Genetic Disorder 7.48E-16 - 1.99E-02 213
Skeletal and Muscular Disorders 3.73E-15 - 1.99E-02 123
Gastrointestinal Disorder 8.25E-15 - 1.99E-02 133
Molecular and Cellular Signaling p-value #genes
Cell-To-Cell Signaling and Interaction 7.26E-20 - 1.99E-02 68
Cellular Assembly and Organization 5.56E-16 - 1.99E-02 82
Cellular Movement 1.28E-12 - 1.99E-02 44
Molecular Transport 2.71E-07 - 1.99E-02 67
Small Molecule Biochemistry 2.71E-07 - 1.99E-02 54
Canonical Pathways p-value Ratio
Axonal Guidance Signaling 1.26E-06 23/433
CDK5 Signaling 3.87E-05 9/94
Cardiac b-adrenergic Signaling 4.55E-05 11/154
Corticotropin Releasing Hormone Signaling 2.09E-04 9/136
Dopamine Receptor Signaling 6.05E-04 7/95
224 UPPER GENES
Molecular and Cellular Signaling p-value #genes
Cell-To-Cell Signaling and Interaction 4.31E-17 - 2.12E-02 51
Cellular Assembly and Organization 3.34E-11 - 2.12E-02 60
Cellular Movement 5.21E-10 - 1.42E-02 35
Cellular Function and Maintenance 4.02E-08 - 2.20E-02 49
Molecular Transport 4.02E-08 - 1.75E-02 49
Canonical Pathways p-value Ratio
Corticotropin Releasing Hormone Signaling 1.16E-04 8/136
CDK5 Signaling 1.76E-04 7/94
Synaptic Long Term Depression 1.62E-03 7/147
Cardiac b-adrenergic Signaling 2.35E-03 7/154
Axonal Guidance Signaling 2.65E-03 13/433
49 MID GENES
Molecular and Cellular Signaling p-value #genes
Cellular Development 9.09E-07 - 4.47E-02 12
Cell Morphology 3.82E-06 - 3.88E-02 16
Cellular Assembly and Organization 1.16E-05 - 4.18E-02 16
Cellular Movement 4.59E-05 - 4.76E-02 9
Cell-To-Cell Signaling and Interaction 4.00E-04 - 4.76E-02 13
Canonical Pathways p-value Ratio
Axonal Guidance Signaling 1.28E-07 10/433
Semaphorin Signaling in Neurons 1.54E-05 4/52
Inositol Phosphate Metabolism 7.95E-03 3/180
CXCR4 Signaling 9.66E-03 3/169
Regulation of Actin-based Motility by Rho 2.29E-02 2/91
44 DEEP GENES
Molecular and Cellular Signaling p-value #genes
Carbohydrate Metabolism 3.00E-05 - 3.88E-02 7
Molecular Transport 3.00E-05 - 3.88E-02 11
Small Molecule Biochemistry 3.00E-05 - 4.34E-02 12
DNA Replication, Recombination and Repair 1.37E-04 - 1.81E-02 2
Nucleic Acid Metabolism 1.37E-04 - 2.32E-02 7
Canonical Pathways p-value Ratio
Protein Kinase A Signaling 8.73E-05 6/328
Cardiac b-adrenergic Signaling 3.18E-04 4/154
G-Protein Coupled Receptor Signaling 1.43E-03 6/530
cAMP-mediated signaling 1.94E-03 4/219
Synaptic Long Term Potentiation 2.08E-03 3/114

In each panel the most salient “Molecular and Cellular Signaling” and “Canonical Pathways” categories are indicated, along with the associated p values. a, “all”. b, “upper group.” c, “middle group.” d, “deep group.”.

Cameron et al.

Cameron et al. BMC Neuroscience 2012 13:90   doi:10.1186/1471-2202-13-90

Open Data