Adult cD2KO mice have reduced numbers of dentate granule cells (DGCs). Absolute numbers of DGCs were estimated in mice aged P88 or P288. At both ages, they were significantly reduced due to the lack of functional cD2 (*p < 0.001). In WT animals, the number of DGCs increased with advancing age (#p < 0.05). We found no evidence for such an age-related change in cD2KO mice.
Ansorg et al. BMC Neuroscience 2012 13:46 doi:10.1186/1471-2202-13-46