Additional file 2.

Figure 2. SLPI administration increases severity of active PLP-induced EAE of SJL/J mice. A: Female SJL/J mice were immunized with PLP-peptide. Between 0 and 16 days, SLPI mice were injected three times a day with recombinant SLPI (100 μL of 3.3 μg/mL in 0.9% saline); control mice were injected with 0.9% saline instead. Data is shown as mean ± S.E. of the mean. The differences between the SLPI and the control group were statistically significant on day 19 after disease induction (Mann-Whitney rank sum test, p < 0.05). B: Mouse sera collected 30 days after EAE induction were analyzed by ELISA for the presence of SLPI-specific antibodies, as described in Materials and Methods. IgG titers representing the average of samples from five different mice were compared

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Müller et al. BMC Neuroscience 2012 13:30   doi:10.1186/1471-2202-13-30