Knockdown of C/EBP reduced net growth of the distal, proximal, and intact neurites following axotomy. Representatives of transected axons in culture. Immediately following axotomy (t = 0), either CM, control siRNA, C/EBP siRNA #1, or C/EBP siRNA #2 was added into culture medium at a final concentration of 7 nM, immediately after neurite transection. The neurons were observed over additional 36 hours and images were taken at 10, 24 and 36 hours as indicated. Arrows denote the transection site.
Aleksic and Feng BMC Neuroscience 2012 13:2 doi:10.1186/1471-2202-13-2