Open Access Highly Accessed Research article

Increased cerebral blood flow in the right frontal lobe area during sleep precedes self-awakening in humans

Sayaka Aritake1234*, Shigekazu Higuchi15, Hiroyuki Suzuki1, Kenichi Kuriyama6, Minori Enomoto14, Takahiro Soshi6, Shingo Kitamura1, Akiko Hida1 and Kazuo Mishima1

Author affiliations

1 Department of Psychophysiology, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, 187-8502, Japan

2 Japan Society for the Promotion of Science, Tokyo, 102-8471, Japan

3 Department of Somnology, Tokyo Medical University, Tokyo, 160-0023, Japan

4 Department of Life Sciences and Bio-informatics, Graduate School of Allied Health Sciences, Tokyo Medical and Dental University, Tokyo, 113-0034, Japan

5 Department of Human Science, Faculty of Design, Kyushu University, Fukuoka, 815-8540, Japan

6 Department of Adult Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, 187-8502, Japan

For all author emails, please log on.

Citation and License

BMC Neuroscience 2012, 13:153  doi:10.1186/1471-2202-13-153

Published: 21 December 2012

Abstract

Background

Some people can subconsciously wake up naturally (self-awakening) at a desired/planned time without external time stimuli. However, the underlying mechanism regulating this ability remains to be elucidated. This study sought to examine the relationship between hemodynamic changes in oxyhemoglobin (oxy-Hb) level in the prefrontal cortex and sleep structures during sleep in subjects instructed to self-awaken.

Results

Fifteen healthy right-handed male volunteers with regular sleep habits participated in a consecutive two-night crossover study. The subjects were instructed to wake up at a specified time (“request” condition) or instructed to sleep until the morning but forced to wake up at 03:00 without prior notice (“surprise” condition). Those who awoke within ± 30 min of the planned waking time were defined as those who succeeded in self-awakening (“success” group). Seven subjects succeeded in self-awakening and eight failed.

No significant differences were observed in the amounts of sleep in each stage between conditions or between groups. On the “request” night, an increase in oxy-Hb level in the right prefrontal cortex and a decrease in δ power were observed in the “success” group around 30 min before self-awakening, whereas no such changes were observed in the “failure” group. On the “surprise” night, no significant changes were observed in oxy-Hb level or δ power in either group.

Conclusions

These findings demonstrate a correlation between self-awakening and a pre-awakening increase in hemodynamic activation in the right prefrontal cortex, suggesting the structure’s contribution to time estimation ability.

Keywords:
Time estimation ability; Self-awakening; Sleep; Cognitive science; Prefrontal cortex; Insomnia