Highly significant correlations between Ercc1 (left) or Mcm5 (right) expression in human PBLs and the volume of the left parietal inferior supramarginal gyrus. The histogram plots (inset) show the results of an ANOVA comparing the expression levels of Ercc1 and Mcm5 in all three subject groups. Note that both genes showed a significant main effect of diagnosis, but there was a clear trend for alcohol dependent (AD) subjects to show more of a decrease in expression compared to controls (Ctrls) than alcohol abusing (AA) subjects.
Hicks et al. BMC Neuroscience 2012 13:128 doi:10.1186/1471-2202-13-128