Post-treatment with 9cRA reduced methamphetamine –induced ipislateral rotation in hemiparkinsonian rats. Animals were lesioned by local administration of 6-OHDA at the left medial forebrain bundle on day 0. Rotation was induced by administration of 2.5 mg/kg methamphetamine at day 6 (prior treatment) and days 20 and 30 (after treatment). Treatment with 9cRA from day 7 to day 14 (i.c.v. and intranasal) significantly reduced rotation. Bar on X-axis represents the period animals received 9cRA or vehicle.
Yin et al. BMC Neuroscience 2012 13:120 doi:10.1186/1471-2202-13-120