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Open Access Highly Accessed Research article

Early post-treatment with 9-cis retinoic acid reduces neurodegeneration of dopaminergic neurons in a rat model of Parkinson’s disease

Lian-Hu Yin13, Hui Shen1, Oscar Diaz-Ruiz2, Cristina M Bäckman2, Eunkyung Bae1, Seong-Jin Yu1 and Yun Wang1*

Author Affiliations

1 Neural Protection and Regeneration Section, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA

2 Integrative Neuroscience Section, National Institute on Drug Abuse, IRP, Baltimore, MD, USA

3 Department of Neurosurgery, Luhe Teaching Hospital, Capital Medical University, Beijing, China

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BMC Neuroscience 2012, 13:120  doi:10.1186/1471-2202-13-120

Published: 6 October 2012

Additional files

Additional file 1:

Figure S1. Increase 9cRA level in brain after intranasal delivery of 9cRA. A total of 12 rats were given either 9cRA (20 ug per animal) or vehicle intranasally. Brain tissues were harvested at 1, 2 and 4 hours after administration. Tissues were extracted and 9cRA levels in brain homogenates were detected by Mass spectrometry as previously described (Kane, A. Biochem J. 388,363-369, 2005). No detectable 9cRA was found in vehicle treated rats. There is a significant increase in 9cRA level at one and 2 hours after 9cRA administration (p<0.05, one way ANOVA). Brain 9cRA level returned to the basal level at 4 hours after administration.

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