The results of the miR-34a antagomir experiment. Inhibition of miR-34a expression by the miR-34a antagomir at 7 days post-SE in the rat hippocampus is shown in. A. The miR-34a antagomir significantly inhibited the expression of miR-34a in the post-SE rat hippocampus when compared with the antagomir-control (Data are presented as the mean ± SEM, *p < 0.05; n = 6 for each group). The expression of activated caspase-3 protein in the post-SE rat hippocampus both before and after miR-34a antagomir/antagomir-control treatments as detected by western blot analysis is shown in B. Western blot detected an up-regulation in the expression of activated caspase-3 protein at 7 days post-SE in the rat hippocampus, when compared with control (*p <0.05, n = 6 for each group). The expression of activated caspase-3 protein at 7 days post-SE in the rat hippocampus, however, decreased in the miR-34a antagomir-treated group, when compared with the antagomir-control-treated group (**p < 0.05, n = 6 for each group).
Hu et al. BMC Neuroscience 2012 13:115 doi:10.1186/1471-2202-13-115