Imipramine and dicholine succinate counteract stress-induced decrease in sucrose preference and sucrose intake. (A) Groups of mice assigned for planned treatment had similar means of sucrose preference before the beginning of dosing. (B) Two-way ANOVA revealed a significant effect for the stress condition in sucrose preference F = 11.9, DFn = 1, DFd = 12, p =0.0058 * vs respected control. (C) NoT stress mice showed a significant reduction for sucrose preference at days 7 and 10 in relation to the stress condition F = 12.75, DFn = 1, DFd = 87, p =0.0006, Bonferroni day 7, p < 0.05 * respected control; day 10, p < 0.01 ** vs control. (D,E) Imi and DS stress mice did not show significant differences neither at day 7 nor day 10 for the stress condition F = 1.686, DFn = 1, DFd = 89, p = 0.1975 and F = 2.252, DFn = 1, DFd = 90, p = 0.1369 respectively. (F) Following chronic stress, the total sucrose intake was measured and two-way ANOVA revealed an overall condition effect while Bonferroni showed a significant reduction in sucrose intake only in the NoT stress group F = 5.352, DFn = 1, DFd = 88, p = 0.0230, Bonferroni: NoT p < 0.05, DS, Imi p > 0.05 * vs respected control. NoT: non-treated group; Imi: imipramine-treated group, DS: DS-treated group. Data is shown as mean ± SEM.
Cline et al. BMC Neuroscience 2012 13:110 doi:10.1186/1471-2202-13-110