Effect of fluoxetine treatment on LTM performance in senior animals. A. Long-term memory assessment of senior snails following treatment with fluoxetine (+ Fluoxetine) or vehicle only (− Fluoxetine). Fluoxetine treatment significantly improved LTM performance in conditioned (CS-UCS) senior snails. In contrast, vehicle only treated conditioned animals showed no indication of LTM. B. Comparison of spontaneous background rasping rates reveals no significant differences between animals treated with fluoxetine (+ Fluox) or vehicle only (−Fluox). C. Comparison of rasping response after application of the disturbance stimulus reveals no significant differences between unconditioned (CS-DS) and conditioned (CS-UCS) animals regardless whether they were treated with fluoxetine (+ Fluox) or vehicle only (−Fluox). * = p < 0.05, *** = p < 0.001, ns = non-significant.
Watson et al. BMC Neuroscience 2012 13:103 doi:10.1186/1471-2202-13-103