BBB glucose metabolism is affected by TS exposure. The ratio between glucose consumption and lactate production is not affected by vitamins supplementation (C+E) (Panel A). Note that a glucose consumption/lactate production ratio ≈ 1 indicates that at list 50% of glucose undergoes oxidative metabolism (Krebs cycle). TS caused a decrease in glucose consumption paralleled by an in lactate production (Panel B) suggesting that a shift toward a non-oxidative glucose metabolism occurred. This metabolic shift was gradually reversed by antioxidant vitamins supplementation (C+E). The asterisk "*" indicates a statistically significant difference (p < 0.05) versus control. The described experiments were performed in quadruplicates (n = 4).
Hossain et al. BMC Neuroscience 2011 12:92 doi:10.1186/1471-2202-12-92