Model of the proposed pathway by which extracellular ATP activates NFAT in PC12 cells. The results demonstrate the requirement of Ca2+ influx from the extracellular space and the contribution of both calcineurin-NFATc and MEK-ERK1/2 pathways. The scheme also illustrates the inhibitors used for pharmacological characterisation. BTP2 is a blocker of SOCE and inhibits TRPC channels, but its direct molecular target in PC12 cells is not clear.
Prasai et al. BMC Neuroscience 2011 12:90 doi:10.1186/1471-2202-12-90