Figure 4.

Cochlear SST1 and SST2 localization in SST1 and SST2 KO mice. A, E, SST1 (A, red) cannot be detected in the SST1 KO mouse cochlea, and SST2 (E, red) cannot be detected in the SST2 KO mouse cochlea (negative controls). B, F SST2 (B, red) is expressed in outer HCs and Deiters' cells in the SST1 KO cochlea, while SST1 (F, red) is expressed in outer and inner HCs, as well as in supporting cells in the SST2 KO cochlea. C, G, Cell nuclei (DAPI, blue) and calbindin staining (green) in cochleae from SST1 KO (C) and SST2 KO (G) mice. D, H, Composite images of cochleae from SST1 KO (D) and SST2 KO (H) mice. Images by confocal microscopy; scale bar = 100 μm.