Figure 4.

CREB phosphorylation in sustentacular cells after 24 hours. (A) Low magnification representative image of 12 μm cryosection of OMP-GFP mice treated with a mixture of 100 odorants for 24 h. Sustentacular cells showed marked CREB phosphorylation, while phosphorylation in immature OSNs not expressing OMP is only weak and in OSNs decreased. (B) Higher magnification images. Scale bars = 50 μm. (C) Fluorescence intensity was quantified as before. Bar chart shows mean ± SD (Sustentacular cell control 0.96 ± 0.33 n = 78, 24 h odorant 3.87 ± 0.13 n = 73; OSN control 2.58 ± 0.15 n = 72, 24 h odorant 1.13 ± 0.62 n = 70), p** < 0.01, p*** < 0.001.

Dooley et al. BMC Neuroscience 2011 12:86   doi:10.1186/1471-2202-12-86
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