Model of the transcriptional regulation of bim expression by prosurvival signalling pathways in sympathetic neurons. The MEK-ERK pathway negatively regulates bim expression at the level of transcription via the 3' UTR by an unknown mechanism. PI3-K-Akt signalling inhibits FOXO transcription factors which can bind to two conserved FOXO sites in the bim promoter [8,9]. Both prosurvival pathways are activated following the binding of NGF to TrkA and act independently of each other to reduce bim mRNA levels.
Hughes et al. BMC Neuroscience 2011 12:69 doi:10.1186/1471-2202-12-69