Schematic illustration of the electrospinning setup and three major components of the experiment. Electrospun fibers were collected onto a flat plate collector to form meshes, and collected onto a rotating mandrel to form guidance conduits. After scaffold characterizations, the electrospun collagen/PCL meshes were tested with Schwann cells in vitro and guidance conduits were sutured to connect two stumps of a rat sciatic nerve lesion in vivo (the suture was performed as shown in the figure).
Yu et al. BMC Neuroscience 2011 12:68 doi:10.1186/1471-2202-12-68