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Cocaine- and amphetamine-regulated transcript promotes the differentiation of mouse bone marrow-derived mesenchymal stem cells into neural cells

Zhuo Liu1,2,4,5, Danqing Huang3, Meijuan Zhang2,4, Zhibin Chen2,4,5, Jiali Jin2,4, Siyuan Huang2,4, Zhuo Zhang2,4,5, Zhongyuan Wang 2,4,5, Lei Chen6, Ling Chen6 and Yun Xu1,2,4,5*

1 Department of Neurology, Drum Tower Hospital of Nanjing Medical University, 321 Zhongshan Road, Nanjing, Jiangsu, 210008, PR. China

2 Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, Jiangsu, 21008, PR. China

3 Department of Neurology, Jiangsu Province Geriatric Hospital, 65 Jiangsu Road, Nanjing, Jiangsu, 210024, PR. China

4 The State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, 22 Hankou Road, Nanjing, Jiangsu, 210093, PR. China

5 Jiangsu Key Laboratory for Molecular Medicine, Nanjing University, 22 Hankou Road, Nanjing, Jiangsu, 210093, PR China

6 Department of Physiology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, Jiangsu, 210029, PR China

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BMC Neuroscience 2011, 12:67 doi:10.1186/1471-2202-12-67

Published: 14 July 2011

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Additonal File 1:

Excitable properties of MSC-derived neural like cells. (A) Voltage-gated potassium current was evoked by a series of depolarizing pulses from -100 mV to +50 mV stepping by 10 mV with interval time of 5 sec. (B) voltage-gated calcium current was elicited by depolarizing to -40 mV (200 ms) from a holding potential of -80 mV and then further depolarized to 0 mV (200 ms) with interval time of 5 sec.

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