Widespread downregulation of cortical GRIT expression following learning in aged mice. (A), Representative heat maps showing the distribution of GRIT mRNA expression in the aged mouse brain following learning, swimming, or home cage conditions. (B), Densitometric analysis revealed that learning suppressed GRIT expression in all cortical regions examined, including the anterior cingulate cortex (AC), auditory cortex (Au), entorhinal cortex (Ent), motor cortex (M), somatosensory cortex (Ss), retrosplenial cortex (Rs), and visual cortex (Vis). Asterisk (*) indicates significance at p < 0.05 following one-way ANOVA with Tukey's post hoc. Abbreviations used in (A) are the same as those used in (B) and (C); see Materials and Methods for detailed description of cortical anatomical sampling. (C), Levels of GRIT mRNA are reduced following learning, to a similar extent in cortical regions implicated in the associational and sensorimotor aspects of water maze learning.
Park et al. BMC Neuroscience 2011 12:63 doi:10.1186/1471-2202-12-63