Neurological evaluation of mice prior to and after middle cerebral artery occlusion. The upper graph (A) shows the average time scores for adhesive-removal in the 4 animal groups at various surviving points. Mice with BMMCs transplantation combined with G-CSF administration spend less time to remove the adhesive paper on their forearm relative to other groups. The low graph (B) plots the modified neurological severity scores (mNSS) in the 4 animal groups at different time points. The extent of neurological function impairment is significantly less in the BMMCs-G-CSF group relative to other groups, and also reduces with increasing surviving time overall. No differences exist before and at day one after ischemic lesion for either adhesive removal or mNSS scores.
Zhang et al. BMC Neuroscience 2011 12:61 doi:10.1186/1471-2202-12-61