Table 2

Number and diameter of myelinated axons, thickness of their myelin sheaths and score of behavioral test

MCN

Number of myelinated

Axonal diameter

Myelin sheath thickness

BT ± SD

axons (n ± SD)

(μm ± SD)

(μm ± SD)


intact

1259 ± 98

4.08 ± 2.11

1.37 ± 0.64

5.00 ± 0.00

PBS

1473 ± 135‡

1.79 ± 0.03‡

0.61 ± 0.01‡

3.53 ± 0.52‡

Cerebrolysin

1282 ± 124#

2.16 ± 0.03+‡

0.81 ± 0.01+‡#

4.08 ± 0.49‡

CNTF

782 ± 78+‡

2.11 ± 0.03+‡

0.79 ± 0.01+‡

5.00 ± 0.00+


Mean numbers of myelinated axons, their diameters and thickness of myelin sheaths in intact MCN and in MCN stumps after end-to-side anastomosis in phosphate buffered saline (PBS-), Cerebrolysin- and CNTF-treated rats as well as their mean scores for behavioral test (BT).

‡ indicates statistical significance (P < 0.05) when comparing rats of experimental groups with intact rats; + indicates statistical significance (P < 0.05) when comparing rats with ALZET minipumps filled with CNTF or Cerebrolysin and PBS; # indicates statistical significance (P < 0.05) when comparing rats with ALZET minipumps filled with Cerebrolysin and CNTF.

Dubový et al. BMC Neuroscience 2011 12:58   doi:10.1186/1471-2202-12-58

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