Open Access Research article

Ciliary neurotrophic factor promotes motor reinnervation of the musculocutaneous nerve in an experimental model of end-to-side neurorrhaphy

Petr Dubový1*, Otakar Raška2, Ilona Klusáková1, Lubomír Stejskal2, Pavel Čelakovský2 and Pavel Haninec2

Author Affiliations

1 Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine, and Central European Institute of Technology (CEITEC), Masaryk University, Kamenice 3, CZ-625 00 Brno, Czech Republic

2 Department of Neurosurgery, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic

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BMC Neuroscience 2011, 12:58  doi:10.1186/1471-2202-12-58

Published: 22 June 2011

Additional files

Additional file 1:

Table S1 - Quantitative analysis of labeled spinal motoneurons and DRG neurons. Quantitative analysis of labeled spinal motoneurons and DRG neurons of intact rats (n = 6) and rats following UN-MCN end-to-side anastomosis and intrathecal treatment with PBS, Cerebrolysin and CNTF. Red-labeled perikarya belong to neurons with single axons present in the UN; green-labeled perikarya belong to neurons whose single axons were damaged during surgical treatment and regenerated only into the MCN distal stump; yellow-labeled perikarya resulted from a mixture of red and green fluorescence and indicate those UN neurons whose axons gave off an additional daughter branch that adjoined and grew into the distal stump of MCN. † indicates statistical significance (P < 0.05) when comparing rats with ALZET minipumps filled with CNTF and Cerebrolysin or PBS.

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