A-H. Confocal images showing the MKP-1 expression (red) in lectin-positive (green) microglia in corpus callosum of 3 day postnatal and in OX42 postive (green) microglia in the corpus callosum of 4 week old rat brain subjected to different treatments. MKP-1 immunoreactivity is hardly detectable in microglia of control rats injected with saline (A, E) and with Dex alone (B,F). MKP-1 immunoreactivity appears to be upregulated in microglia distributed in the corpus callosum region of rats that received LPS (C, G) or LPS and Dex (D, H).Scale bar (A-D), 50 μm; Scale bar (E-H), 20 μm.
Huo et al. BMC Neuroscience 2011 12:49 doi:10.1186/1471-2202-12-49