A-H Quantitative western blot analysis showing the suppressive effect of Dex on the phospho-JNK and - p38 protein expression in LPS treated BV-2 cells. Maximum induction of both phospho-JNK (A,B) and -p38 (E,F) protein expression was observed in microglia exposed to LPS for 3 h. The induction of both phospho-JNK (C,D) and -p38 (G,H) protein expression in microglia was found to be suppressed by Dex in a dose dependent manner. Panels A, C, E and G represent the Western blot of phospho-JNK and phospho-p38 protein of each experiment with corresponding quantitative analyses of total-p38 and -JNK proteins (Panels B, D, F and H), respectively. The data represent the mean ± SD (n = 3) * p < 0.05.
Huo et al. BMC Neuroscience 2011 12:49 doi:10.1186/1471-2202-12-49