Shear stress increases cytoskeleton protein expression while decreasing that of cytosol, nucleus and membrane. Note the drastic changes related to cytoskeletal protein expression. In EC grown under flow condition cytoskeletal proteins represent account for majority of the total protein content. Note also that the exposure to flow significantly decreased the overall expression of nuclear, cytosolic and membrane proteins. This is consistent with endothelial morphologic adaptation to flow and with a reduced cell proliferation. Note that "*" and "**" refers to a statistically significant (n = 4; P < 0.05) changes (increase and decrease respectively) in the protein content.
Cucullo et al. BMC Neuroscience 2011 12:40 doi:10.1186/1471-2202-12-40