Shear stress enables endothelial-leukocyte interaction. Shear stress increased the transcription level of relevant adhesion molecules (Panel A) and integrins (Panel B) thus facilitating the cross-talk between the vascular endothelium and the host immune system at the BBB level. Note that "*" and "**" refers to a statistically significant (n = 4; p < 0.05) changes (increase and decrease respectively) of adhesion molecules and integrins genes transcription in EC exposed to flow versus those grown under static conditions.
Cucullo et al. BMC Neuroscience 2011 12:40 doi:10.1186/1471-2202-12-40