Shear stress enables vascular-dependent shielding of brain from unwanted and potentially harmful substances. Shear stress increases the RNA levels of gene encoding for multidrug resistance proteins (panel A) and cytochrome P450 enzymes (panel B). Note that "*" refers to a statistically significant (n = 4; p < 0.05) increase of the genes transcription in EC exposed to flow versus those grown under static conditions.
Cucullo et al. BMC Neuroscience 2011 12:40 doi:10.1186/1471-2202-12-40