Table 1

APP+ vesicle formation in MND autopsies

CASE #

AGE

GENDER

PM [h]

PATHOLOGICAL DIAGNOSIS

DEG.

APP+ VESICLES

VPS54 SEQ. ALTERATION


1

74

M

83

MND

-3

+

n.d.

2

49

M

32

MND

-3

-

None

3

58

M

37

MND

-2

-

n.d.

4

69

F

17

MND

-3

+

n.d.

5

48

M

25

MND

-2

+

None

6

81

F

30

MND

-2

-

None

7

55

M

39

MND

-2

-

None

8

72

F

6

MND

-1

-

n.d.

9

68

F

70

MND

-3

+

None

10

54

M

30

MND

-1

-

n.d.

11

51

F

24

MND

-3

+

None

12

54

M

95

MND

-2

+

n.d.

13

54

F

?

MND Familial

-3

-

n.d.

14

56

M

79

MND Familial

-2

-

n.d.

15

89

F

54

PD

-1

-

None

16

85

F

9

PD

-2

-

None

17

61

M

65

Amyloid plaques

0

-

n.d.

18

79

M

24

Mild ageing changes

0

-

n.d.

19

80

M

48

changes consistent with ageing

0

-

n.d.

20

40

M

40

Normal adult brain

0

-

n.d.

21

57

M

26

Normal adult brain

0

-

n.d.

22

87

F

21

Normal adult brain

0

-

None

23

68

M

53

Normal adult brain

0

-

n.d.

24

64

F

60

Normal adult brain

0

-

n.d.

25

61

M

35

Normal adult brain

0

-

n.d.

26

58

F

21

Mild ischemia

0

-

None

27

68

M

40

Diffuse hypoxic damage

0

-

n.d.

28

61

M

65

None given

0

-

n.d.


Legend: Histological assessment of human Motor neuron disease (MND) autopsies from spinal cord. Spinal cord sections were fixed in formalin after the post-mortem time indicated ("PM", in hours [h]) and later embedded in paraffin. The grades of Motor neuron degeneration were judged by Nissl staining and designated as 0 (no degeneration), -1 (single degenerating neurons), -2 (more than one degenerating motor neuron per ventral horn), -3 (groups of degenerating motor neurons). Note that in non-ALS brains including normal adult brain or other origins of neurodegeneration, APP+ vesicles have not been detected.

Palmisano et al. BMC Neuroscience 2011 12:24   doi:10.1186/1471-2202-12-24

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