Reduced levels of MBP and compact myelin in Fa2h-/-/Cgt-/- and Cgt-/- mice. (A) Western blot analysis of 4-week-old wild-type (lanes 1 and 2), Cgt-/- (lanes 3 and 4), and Fa2h-/-/Cgt-/- mice (lanes 5 and 6) brain homogenates showed reduced MBP levels in Cgt-/- and Fa2h-/-/Cgt-/- mice. Shown is one representative out of three independent experiments, all of which gave comparable results. (B) The dry weight of purified myelin per mg brain wet weight isolated from Cgt-/- and Fa2h-/-/Cgt-/- mice (n = 3 per genotype) was significantly reduced compared to wild-type controls (*p < 0.05, t-test).
Meixner et al. BMC Neuroscience 2011 12:22 doi:10.1186/1471-2202-12-22