Figure 1.

Pathway of sphingolipid biosynthesis in myelinating glia cells. Changes in sphingolipids observed in Cgt-/- mice (blue arrows) and expected possible changes in Fa2h-/-/Cgt-/- mice (red arrows). Shown are the genetic symbols of genes encoding the respective enzymes: Cgt, UDP-galactose:ceramide galactosyltransferase; CerS, ceramide synthase; Des1, dihydroceramide desaturase; Fa2h, fatty acid 2-hydroxylase; Gal3st1, galactose-3-O-sulfotransferase 1; Sgms, sphingomyelin synthase; Ugcg, UDP-glucose ceramide glucosyltransferase.

Meixner et al. BMC Neuroscience 2011 12:22   doi:10.1186/1471-2202-12-22
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