Table 2

Gene expression of IL-1β, IL-6, TNF-α, CD11B, MMP-9 and GFAP after 2 h of tMCAO and 24 h post-reperfusion

Vehicle

Solulin


Gene

Contralateral [%]

Ipsilateral [%]

Contralateral [%]

Ipsilateral [%]

IL-1β

100

1165.5 ± 1522.1

46.6 ± 42.8

242.7 ± 443.4

IL-6

100

775.2 ± 724.4

26.1 ± 22.2

411.7 ± 550.6

TNF-α

100

206.2 ± 278.9

86.1 ± 92.4

83.9 ± 56.9

MMP-9

100

257.6 ± 131.1

41.9 ± 46.5

201.6 ± 97.1

CD11B

100

236.2 ± 56.1

86.6 ± 85.5

119.6 ± 102.8

GFAP

100

108.4 ± 69.5

71.7 ± 89.7

87.1 ± 89.7


Gene expression of three consecutive coronal sections of TTC-stained hemispheres. The contralateral non-infarcted hemispheres of the vehicle-treated group acted as internal controls. Values of these hemispheres were therefore set to 100%. All other values (infarcted hemisphere vehicle-treated group, infarcted and non-infarcted hemisphere of the Solulin cohort) were expressed as percentages of the latter. RT-PCR values were normalized to the housekeeping gene HPRT and cyclophilin A. All mRNA levels are given as means ± SD.

Ryang et al. BMC Neuroscience 2011 12:113   doi:10.1186/1471-2202-12-113

Open Data