Table 4

Contractile effects of Ang II in MCA

N

K+ mean ±

s.e.m

Emax (%) ±

s.e.m

pEC50 ±

s.e.m


Ang II after PD123319 MCA

Sham

6

2.34 ± 0.38

3 ± 2a

SAH

6

1.33 ± 0.28

53 ± 12a,b

7.95 ± 0.38

SAH + SB386023-b at 0 h

SAH + SB386023-b after 6 h

6

6

1, 74 ± 0.11

1.64 ± 0.12

11 ± 4b

13 ± 5b

SAH + SB386023-b after 12 h

6

1.47 ± 0.54

35 ± 5

8, 69 ± 0.14


Responses were characterized by Emax values, expressed as percent of 63 mM K+ -induced contraction, and pEC50 values (negative logarithm of the molar concentration that produces half maximum contraction). Values are represented as mean ± s.e.m and n represents number of animal. a = significant difference between SAH and control groups, b = significant difference between SAH and SAH treated with SB386023-b

Ansar et al. BMC Neuroscience 2011 12:107   doi:10.1186/1471-2202-12-107

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