Open Access Highly Accessed Research article

Effects of collagen-induced rheumatoid arthritis on amyloidosis and microvascular pathology in APP/PS1 mice

Sun Mi Park13, Jin Hee Shin3, Gyeong Joon Moon2, Sung Ig Cho3, Yong Beom Lee3 and Byoung Joo Gwag13*

Author Affiliations

1 Department of Pharmacology, Ajou University School of Medicine, Suwon, South Korea

2 Clinical research center, Samsung biomedical research institute, Seoul, South Korea

3 GNT Pharma, Suwon, South Korea

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BMC Neuroscience 2011, 12:106  doi:10.1186/1471-2202-12-106

Published: 27 October 2011

Additional files

Additional file 1:

Figure S1 - Transient increase of microglial cell proliferation in wild-type mice treated with CIA. Photomicrographs of the dentate gyrus molecular layer immunolabeled with Mac-1 after second injection of CII in CFA in 2-month-old wild-type mice. The number of Mac-1-immunoreactive microglial cells was increased within 1 d after second injection of CII in CFA. This increase remained for over 1 wk, but disappeared within 2 wks (n = 4 per group). Scale bar = 200 μm.

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Additional file 2:

Figure S2 - CIA increases mortality in APP/PS1 mice. Survival analysis of wild-type (Tg-) and APP/PS1 (Tg+) mice treated with vehicle or CIA at 2 months of age (Tg-vehicle, n = 30; Tg-CIA, n = 34; Tg+ vehicle, n = 30; and Tg+ CIA, n = 34).

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