Research article
Effects of collagen-induced rheumatoid arthritis on amyloidosis and microvascular pathology in APP/PS1 mice
1 Department of Pharmacology, Ajou University School of Medicine, Suwon, South Korea
2 Clinical research center, Samsung biomedical research institute, Seoul, South Korea
3 GNT Pharma, Suwon, South Korea
BMC Neuroscience 2011, 12:106 doi:10.1186/1471-2202-12-106
Published: 27 October 2011Additional files
Additional file 1:
Figure S1 - Transient increase of microglial cell proliferation in wild-type mice treated with CIA. Photomicrographs of the dentate gyrus molecular layer immunolabeled with Mac-1 after second injection of CII in CFA in 2-month-old wild-type mice. The number of Mac-1-immunoreactive microglial cells was increased within 1 d after second injection of CII in CFA. This increase remained for over 1 wk, but disappeared within 2 wks (n = 4 per group). Scale bar = 200 μm.
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Additional file 2:
Figure S2 - CIA increases mortality in APP/PS1 mice. Survival analysis of wild-type (Tg-) and APP/PS1 (Tg+) mice treated with vehicle or CIA at 2 months of age (Tg-vehicle, n = 30; Tg-CIA, n = 34; Tg+ vehicle, n = 30; and Tg+ CIA, n = 34).
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