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This article is part of the supplement: Nineteenth Annual Computational Neuroscience Meeting: CNS*2010

Open Access Poster Presentation

Neural field model of rat's cortex based on realistic connectivity from diffusion weighted MRI and neural morphology

Manh Nguyen Trong12*, Andreas Spiegler12 and Thomas R Knösche1

Author Affiliations

1 Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

2 Institute for Biomedical Engineering and Informatics, Technical University of Ilmenau, Ilmenau, Germany

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BMC Neuroscience 2010, 11(Suppl 1):P41  doi:10.1186/1471-2202-11-S1-P41

The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1471-2202/11/S1/P41


Published:20 July 2010

© 2010 Trong et al; licensee BioMed Central Ltd.

Poster Presentation

Generative models of neural circuits may help to create a link between neural mechanisms and observable data. We propose a model of rat's cortex using a neural field model containing biologically plausible anatomical connections from tractography based on dwMRI data and from the neural morphological database NeuroMorpho [1].

There are three principal types of anatomical connections in the cortex: Local, long-range and distal connections [2].

For specifying local connections we use neural morphologies from [1]. We consider each voxel in the model as a neural mass and distribute randomly drawn neurons from the database therein. After that we use bootstrap methods to determine the total number and variability of synaptic contacts. For the distal connectivity we estimated the degree of anatomical connectedness using white matter tractography on the basis of diffusion weighted MRI [3].

Our neural field consists of 5 layers. For each layer we assume three different neural masses: pyramidal cells, excitatory and inhibitory interneurons [4]. The mutual interactions between neural masses will be described by a system of integral differential equations:

where V is the state vector (mean membrane potentials), T the time delays in the dendritic arbors, S the sigmoidal output function, W the connection coefficients between the neural elements, I the input, and t(d) is the distance dependent time delays. Figure 1A shows the estimated spatial dependency of local connectivity, which is in accordance with anatomical observations [2]. The distal connectivity map of 28 regions is displayed in Fig. 1B. An example map of simulated activity on the cortex in response to a stimulus to somatosensory cortex is illustrated in Fig. 1C.

thumbnailFigure 1. (A) Local connectivity profile between a pyramidal cell in layer V and an interneuron in layer III (grid size 250 µm). (B) Distal connectivity map estimated from dwMRI between 28 regions. (C) Spatio-temporal activity pattern 100 ms after the onset of a constant input to the pyramidal cells of layer 5 of the somatosensory cortex, as simulated by the neural field model.

To summarize, we developed a method for estimating the local connectivity and constructed a neural field model of the entire cortex enriched by estimated local and distal connectivities. With this model we are able to simulate spatio-temporal activity patterns. This is a first step for a comprehensive dynamic brain model and thereby for understanding complex brain processes.

References

  1. Neuromorpho Database: Neural data base. [http://www.neuromorpho.org] webcite

    2009.

  2. Armut Schüz, Robert Miller: Cortical areas: unity and diversity.

    In Edited by Taypor and Francis. 2002.

  3. Kaden E, Knösche TR, Anwander A: Bayesian analyis of anatomical connectivity using diffusion MRI.

    NeuroImage 2007, 37(2):474-488. PubMed Abstract | Publisher Full Text OpenURL

  4. Spiegler A, Kiebel SJ, Atay FM, Knösche TR: Bifurcation analysis of neural mass models: Impact of extrinsic inputs and dendritic time constants.

    NeuroImage 2010, in press.

    Corrected Proof DOI: 10.1016/j.neuroimage.2009.12.081.

    PubMed Abstract | Publisher Full Text OpenURL