Email updates

Keep up to date with the latest news and content from BMC Neuroscience and BioMed Central.

This article is part of the supplement: Nineteenth Annual Computational Neuroscience Meeting: CNS*2010

Open Access Poster Presentation

The impact of pooling and shared inputs on correlations in neuronal networks

James Trousdale*, Robert Rosenbaum and Krešimir Josíc

Author Affiliations

Department of Mathematics, University of Houston, Houston, TX 77004, USA

For all author emails, please log on.

BMC Neuroscience 2010, 11(Suppl 1):P12  doi:10.1186/1471-2202-11-S1-P12


The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1471-2202/11/S1/P12


Published:20 July 2010

© 2010 Trousdale et al; licensee BioMed Central Ltd.

Poster Presentation

A cortical neuron receives inputs from thousands of afferents. Experiments suggest that the activity of these afferent cells is often correlated, although such correlations may be weak. Similarly, recordings of field potentials or data obtained using voltage sensitive dyes represents the pooled activity of large populations of cells, which can be correlated. It is therefore important to understand how correlations between cells in a population affect the statistics of the pooled activity of cells taken from the population.

It is well known that even weak correlations within an input pool can increase the variability of the pooled signal. This phenomenon and its implications for the response and coding capabilities of a downstream cell were investigated in [1][2][3].

Here we address a related phenomenon: weak correlations within and between two populations of neurons lead to significant correlations between the two pooled signals [4]. This phenomenon has been observed in the context of correlations between two VSD [5] and MUA [6] signals. We focus primarily on the effect pooling in input populations has on the covariation of the membrane potentials of two downstream cells. We use simple probabilistic formulae to provide an intuitive explanation for this phenomenon, and show that the contribution of overlap in input populations to the development of correlations is minor relative to the contribution of pooling.

In addition, we apply our results to provide insight on development of correlations and synchrony in feed-forward networks. We show that pooling, and not overlap in input populations, contributes most to the development of very high correlations observed in feed-forward networks. We exhibit via simulations that not only correlations, but also synchrony, develop in the absence of overlap in the input populations. (Figure 1) In a related example, we show that in more structured feed-forward networks including local disynpatic inhibitory circuits, moderate synchrony (i.e., correlations over short time windows) is a strong requirement for the propagation of inputs.

thumbnailFigure 1. Development of synchrony in a feed-forward network with no overlap.

References

  1. Shadlen MN, Newsome WT: The variable discharge of cortical neurons: implications for connectivity, computation, and information coding.

    J Neurosci 1998, 18:3870-3896. PubMed Abstract | Publisher Full Text OpenURL

  2. Salinas E, Sejnowski TJ: Impact of correlated synaptic input on output firing rate and variability in simple neuronal models.

    J Neurosci 2000, 20:6193-6209. PubMed Abstract | Publisher Full Text OpenURL

  3. Moreno-Bote R, Renart A, Parga N: Theory of input spike auto- and cross-correlations and their effect on the response of spiking neurons.

    Neural Comput 2008, 20:1651-1705. PubMed Abstract | Publisher Full Text OpenURL

  4. Renart A, de la Rocha J, Bartho P, Hollender L, Parga N, Reyes A, Harris KD: The asynchronous state in cortical circuits.

    Science 2010, 327:587-590. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  5. Chen Y, Geisler WS, Seidemann E: Optimal decoding of correlated neural population responses in the primate visual cortex.

    Nat Neurosci 2006, 9:1412-1420. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  6. Stark E, Globerson A, Asher I, Abeles M: Correlations between groups of premotor neurons carry information about prehension.

    J Neurosci 28:10618-10630. PubMed Abstract | Publisher Full Text OpenURL