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This article is part of the supplement: Nineteenth Annual Computational Neuroscience Meeting: CNS*2010

Open Access Poster Presentation

Correlation transfer from basal ganglia to thalamus in Parkinson’s disease

Pamela Reitsma*, Jonathan Rubin and Brent Doiron

Author Affiliations

Department of Mathematics, University of Pittsburgh, Pittsburgh, PA 15260, USA

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BMC Neuroscience 2010, 11(Suppl 1):P114  doi:10.1186/1471-2202-11-S1-P114

The electronic version of this article is the complete one and can be found online at:

Published:20 July 2010

© 2010 Reitsma et al; licensee BioMed Central Ltd.

Poster Presentation

Alterations in the temporal structure of activity within the basal ganglia have been implicated in the symptoms of Parkinson’s disease. Past computational work has suggested that changes in the pattern of firing of neurons in the basal ganglia, and hence in the pattern of basal ganglia inputs to thalamus, may compromise thalamocortical relay capabilities [1,2]. To understand how changes in basal ganglia and thalamic activity affect correlation transfer, we study a model of two thalamocortical relay neurons receiving correlated inhibitory input from basal ganglia, as well as excitatory signals. We observe that inhibitory inputs with temporal structure representative of parkinsonian conditions allow for a stronger transfer of correlation at long timescales and higher correlation susceptibility than do inputs found under normal conditions, and we analyze these changes within a reduced model framework.


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