Ultrastructure appearance of RGCs 72 hrs after NMDA injection. Neurons are found at different stages of degeneration and the neuronal death is morphologically 'necrotic'. Figure A shows the hyperconvoluted nucleus and cytoplasm filled with multiple vacuoles, ribosomes and swollen organelle. Figure B shows severe necrotic cell death where the cell has lost its architecture and converted into debris. There is no demarcation between cytoplasm and electron-dense bodies. The cytoplasm is studded with the multi-laminated myelin figures and damaged organelles (Bars = 2 μm); Nu = nucleus, ER = endoplasmic reticulum, ga = golgi apparatus, m = mitochondria, v = vesicles, r = ribosomes.
Saggu et al. BMC Neuroscience 2010 11:97 doi:10.1186/1471-2202-11-97