Functional categories of proteins identified in PSI-induced inclusions. This pie chart shows that all the identified proteins are classified into at least nine accepted categories as follows: 3.6% for synaptic function and neurotransmission (I); 8.8% for gene transcription (II); 3.6% for protein trafficking (III); 21.4% for mitochondrial function and metabolism (IV); 1.8% for antioxidant defense mechanisms (V); 5.4% for apoptotic signal transduction (VI); 10.7% for ubiquitin dependent protein degradation (VII); 30.4% for protein folding and transport (VIII); and 14.3% for unknown function (IX). When a protein could be divided into more than one class of functions, it was indicated as the best known class.
Li et al. BMC Neuroscience 2010 11:95 doi:10.1186/1471-2202-11-95