Table 1

Effects of pantethine treatment on L-3-hydroxybutyryl-CoA dehydrogenase activity.

Days after 2'methyl

-MPTP injection

L-3-hydroxybutyryl-CoA dehydrogenase activity


Brain

(nmol.min-1.mg protein-1)

Liver

(μmol.min-1.mg protein-1)


Saline

Pantethine

Saline

Pantethine

d0

63.91 ± 4.90

73.95 ± 2.55#

2.96 ± 0.35

3.11 ± 0.27

d1

28.91 ± 3.54**

51.09 ± 4.87##

2.74 ± 0.14

3.56 ± 0.18#

d2

35.58 ± 3.31**

45.82 ± 3.84#

2.08 ± 0.17**

2.94 ± 0.19##

d4

45.01 ± 5.19*

46.01 ± 5.05

1.60 ± 0.27**

2.98 ± 0.32##

d7

54.31 ± 4.95

57.55 ± 3.65

2.67 ± 0.18

2.85 ± 0.17


Brain and liver mitochondria were isolated from 2'-methyl-MPTP- injected mice, previously treated with saline or pantethine. Tissue and blood samples were collected from day 0 to day 7 following the neurotoxin injection and were then processed for dehydrogenase activity, i.e conversion of L-3-hydroxybutytyl-CoA to acetoacetyl-CoA. Values are means ± SD; n = 4 mice per assay. Significant decrease versus d0 control, *p < 0.05 and **p < 0.01; significant increase versus paired saline, #p < 0.05 and ##p < 0.01.

Cornille et al. BMC Neuroscience 2010 11:51   doi:10.1186/1471-2202-11-51

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