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Open Access Highly Accessed Research article

Developmental iodine deficiency and hypothyroidism impair neural development in rat hippocampus: involvement of doublecortin and NCAM-180

Jian Gong1, Wanyang Liu1, Jing Dong1, Yi Wang1, Hongde Xu1, Wei Wei1, Jiapeng Zhong1, Qi Xi12 and Jie Chen1*

Author affiliations

1 Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China

2 Department of Physiology, the University of Tennessee Health Science Center, Memphis, TN 38163, USA

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Citation and License

BMC Neuroscience 2010, 11:50  doi:10.1186/1471-2202-11-50

Published: 23 April 2010

Abstract

Background

Developmental iodine deficiency results in inadequate thyroid hormone (TH), which damages the hippocampus. Here, we explored the roles of hippocampal doublecortin and neural cell adhesion molecule (NCAM)-180 in developmental iodine deficiency and hypothyroidism.

Methods

Two developmental rat models were established with either an iodine-deficient diet, or propylthiouracil (PTU)-adulterated water (5 ppm or 15 ppm) to impair thyroid function, in pregnant rats from gestational day 6 until postnatal day (PN) 28. Silver-stained neurons and protein levels of doublecortin and NCAM-180 in several hippocampal subregions were assessed on PN14, PN21, PN28, and PN42.

Results

The results show that nerve fibers in iodine-deficient and 15 ppm PTU-treated rats were injured on PN28 and PN42. Downregulation of doublecortin and upregulation of NCAM-180 were observed in iodine-deficient and 15 ppm PTU-treated rats from PN14 on. These alterations were irreversible by the restoration of serum TH concentrations on PN42.

Conclusion

Developmental iodine deficiency and hypothyroidism impair the expression of doublecortin and NCAM-180, leading to nerve fiber malfunction and thus impairments in hippocampal development.