Email updates

Keep up to date with the latest news and content from BMC Neuroscience and BioMed Central.

Open Access Highly Accessed Research article

JAM-A is a novel surface marker for NG2-Glia in the adult mouse brain

Sandra Stelzer1, Klaus Ebnet2 and Jens C Schwamborn1*

Author Affiliations

1 Westfälische Wilhelms-Universität Münster, ZMBE, Institute for Cell Biology, Stem Cell Biology and Regeneration Group, Von-Esmarch-Str. 56, 48149 Münster, Germany

2 Westfälische Wilhelms-Universität Münster, ZMBE, Institute of Medical Biochemistry, Cell Adhesion and Cell Polarity Group, Von-Esmarch-Str. 56, 48149 Münster, Germany

For all author emails, please log on.

BMC Neuroscience 2010, 11:27  doi:10.1186/1471-2202-11-27

Published: 26 February 2010

Abstract

Background

Junctional adhesion molecule-A (JAM-A) is an adhesive protein expressed in various cell types. JAM-A localizes to the tight junctions between contacting endothelial and epithelial cells, where it contributes to cell-cell adhesion and to the control of paracellular permeability.

Results

So far, the expression pattern of JAM-A has not been described in detail for the different cell types of the adult brain. Here we show that a subset of proliferating cells in the adult mouse brain express JAM-A. We further clarify that these cells belong to the lineage of NG2-glia cells. Although these mitotic NG2-glia cells express JAM-A, the protein never shows a polarized subcellular distribution. Also non-mitotic NG2-glia cells express JAM-A in a non-polarized pattern on their surface.

Conclusions

Our data show that JAM-A is a novel surface marker for NG2-glia cells of the adult brain.