JAM-A is a novel surface marker for NG2-Glia in the adult mouse brain
1 Westfälische Wilhelms-Universität Münster, ZMBE, Institute for Cell Biology, Stem Cell Biology and Regeneration Group, Von-Esmarch-Str. 56, 48149 Münster, Germany
2 Westfälische Wilhelms-Universität Münster, ZMBE, Institute of Medical Biochemistry, Cell Adhesion and Cell Polarity Group, Von-Esmarch-Str. 56, 48149 Münster, Germany
BMC Neuroscience 2010, 11:27 doi:10.1186/1471-2202-11-27Published: 26 February 2010
Junctional adhesion molecule-A (JAM-A) is an adhesive protein expressed in various cell types. JAM-A localizes to the tight junctions between contacting endothelial and epithelial cells, where it contributes to cell-cell adhesion and to the control of paracellular permeability.
So far, the expression pattern of JAM-A has not been described in detail for the different cell types of the adult brain. Here we show that a subset of proliferating cells in the adult mouse brain express JAM-A. We further clarify that these cells belong to the lineage of NG2-glia cells. Although these mitotic NG2-glia cells express JAM-A, the protein never shows a polarized subcellular distribution. Also non-mitotic NG2-glia cells express JAM-A in a non-polarized pattern on their surface.
Our data show that JAM-A is a novel surface marker for NG2-glia cells of the adult brain.