Table 3

Genes Exhibiting Significant Change in Expression Post-Axotomy

Gene

Treat F

Treat P

Treat FDR

Time F

Time P

Time FDR

Intx F

Intx P

Intx FDR

Gene Name


Tgfb1

39.26

0.0008

0.012

0.37

0.7775

0.975

0.29

0.8294

0.959

Transforming growth factor beta-1

Gfra2

58.9

0.0006

0.013

18.01

0.0041

0.182

5.2

0.0537

0.478

GDNF family receptor alpha-2

Artn

53.09

0.0008

0.014

2.46

0.1782

0.721

3.22

0.1205

0.564

Artemin

Tgfbr1

23.1

0.0005

0.015

11.2

0.0011

0.098

17.34

0.0002

0.018

TGF-beta receptor type-1

Crhr1

39.2

0.0015

0.017

0.94

0.489

0.907

0.92

0.4934

0.878

Corticotropin-releasing factor receptor 1

Npffr2

40.59

0.0014

0.018

3.18

0.1223

0.544

0.47

0.7164

0.996

Neuropeptide FF receptor 2 (G-protein coupled receptor 74)

Ntf5

166.32

0.0002

0.018

17.61

0.0091

0.162

14.58

0.0128

0.163

Neurotrophin 4/5

Nrap

17.68

0.0023

0.019

1.13

0.3895

0.889

3.53

0.0618

0.458

Nebulin-related-anchoring protein

Adcyap1r1

32.85

0.0023

0.02

3.25

0.1185

0.555

0.84

0.5267

0.868

Pituitary adenylate cyclase-activating polypeptide type I receptor

HcRt

63.71

0.0005

0.022

8.2

0.0224

0.285

1.89

0.2498

0.717

Orexin (Hypocretin)

Npy1r

29.78

0.0055

0.038

17.98

0.0087

0.194

19.13

0.0078

0.116

Neuropeptide Y receptor type 1

Gfra3

22.14

0.0053

0.039

0.85

0.5251

0.935

9.31

0.0173

0.192

GDNF family receptor alpha-3

Frs2

19.94

0.0066

0.042

17.85

0.0042

0.125

21.47

0.0028

0.083

Fibroblast growth factor receptor substrate 2

Grpr

17.86

0.0083

0.043

0.32

0.8116

0.976

0.71

0.5889

0.92

Gastrin-releasing peptide receptor

Gfra1

16.98

0.0092

0.045

0.34

0.8009

0.976

0.39

0.767

0.922

GDNF family receptor alpha-1

Ntf3

24.74

0.0076

0.045

1.72

0.301

0.893

4.94

0.0785

0.466

Neurotrophin-3

Ntrk1

23.83

0.0081

0.045

8.06

0.0359

0.32

0.45

0.7318

0.972

High affinity nerve growth factor receptor (Trk-A)

Cckar

15.25

0.0113

0.053

0.96

0.4787

0.906

0.46

0.7241

0.991

Cholecystokinin type A receptor

Pycard

9.5

0.0151

0.058

0.52

0.6783

1

1.69

0.2448

0.726

PYD and CARD domain-containing protein

Casp2

9.48

0.0132

0.059

1.38

0.3117

0.895

1.44

0.2955

0.797

Caspase-2

Hspb1

13.15

0.0151

0.061

4.16

0.0794

0.471

15.58

0.0057

0.127

Heat-shock protein 27

Tgfa

11.48

0.0147

0.062

0.31

0.8191

0.959

1.99

0.2174

0.774

Transforming growth factor alpha

Stat4

9.45

0.0218

0.081

0.28

0.8397

0.934

0.08

0.9705

0.993

Signal transducer and activator of transcription 4

Galr2

7.47

0.0257

0.088

4.63

0.037

0.299

1.08

0.4106

0.937

Galanin receptor type 2

Nrg2

6.98

0.0247

0.088

1.19

0.364

0.926

0.61

0.6221

0.955

Pro-neuregulin-2, membrane-bound isoform

Il1b

11.62

0.0271

0.089

2.78

0.1742

0.738

0.91

0.5119

0.876

Interleukin-1 beta


P values for genes exhibiting a significant or nominally significant change in expression post-axotomy. Significant changes in gene expression post-transection were detected using a 2 way ANOVA. As illustrated above, genes were analyzed for a significant effect of treatment (Treat), Time (Time), and Interaction of Treatment and Time (Intx). P-values were then corrected for multiple testing applying the Benjamini-Hochberg FDR algorithm, and are arraigned in order of increasing FDR values based on treatment

Siebert et al. BMC Neuroscience 2010 11:148   doi:10.1186/1471-2202-11-148

Open Data