Comparative post-injury response. The expression profiles illustrate the normalized -ΔΔCp expression values of the post-injury response for both the TPS and LDPT neurons at the same survival times as in Figure 1 and numbered 1-4, with low expression values being represented by green and high expression in red. Significant changes in expression were determined using a 2-factor ANOVA, and then cluster analysis to reveal patterns in the expression profiles. As illustrated in this heat map, the differences in the post-injury response are striking. While many of the genes in LDPT neurons are down-regulated following a T9 level axotomy, the opposite is found in TPS neurons were there is a strong up-regulation following axotomy. The data illustrated in this heat map clearly demonstrate a differential response to a T9 level axotomy.
Siebert et al. BMC Neuroscience 2010 11:148 doi:10.1186/1471-2202-11-148