Effect of GPR3 KO on brain Aβ levels in aged mice. Aβ40 and Aβ42 were determined in one year aged mice for 13 GPR3 wild type (G3+/+) and 13 homozygous GPR3 KO (G3-/-) mice. For comparison, Aβ40 and Aβ42 for five young wild type (B1/2+/+) and four young BACE1, BACE2 homozygous double KO (B1/2 dKO) are shown. Values are expressed as percentage of mean value in the GPR3 wild type mice. One individual GPR3 wild type mouse with a value of 624% was excluded from the analysis.
Toyn et al. BMC Neuroscience 2010 11:143 doi:10.1186/1471-2202-11-143