Additional file 1.

Figure S1A depicts the dose response relationships of XApEn for the same data as used in Figure 5, but filtered with an upper cutoff frequency of 30 Hz and resampled at 100 Hz. Same conventions as for Figure 5 apply, including monoexponential fits represented by solid lines. Qualitatively, the same observations as with the original data set, containing frequencies up to 200 Hz, can be made: decline of XApEn with anesthetic concentration, significant difference between halothane on the one hand and enflurane and isoflurane on the other hand. However, the data are more variable among animals and show less decline with anesthetic frequency. The free parameter tau was [95% confidence intervals]: 2.37 [1.34 3.41] for isoflurane, 2.30 [1.50 3.10] for enflurane and 6.31 [4.67 7.94] for halothane. R2 values were 0.52, 0.68 and 0.51 (same order of agents). Figure S1B shows dose response relations of cross correlation values (normalized to control) computed from the same data as used for Figure 5. While on average the cross correlation increased with anesthetic concentration, there was little dose dependence, and intra- and interindividual variability was extremely high (cf. Figure 3).

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Kreuzer et al. BMC Neuroscience 2010 11:122   doi:10.1186/1471-2202-11-122