Amyloid and Chlamydia pneumoniae immunolabeling in AD tissue. Representative amyloid and C. pneumoniae immunolabeling detected in frontal (A, B) and temporal (C, D) sections of an AD brain. For amyloid labeling (brown color), two different anti-amyloid antibodies were used, (Sigma, panel A) and (Signet, panel C). Representative amyloid immunoreactivity, both extracellular plaques, including dense core plaques (A), and intracellular labeling (C) are revealed at a low magnification in order to appreciate the level of amyloid pathology. Likewise, C. pneumoniae immunoreactivity (magenta color) is evident at low magnification in both brain regions using two different monoclonal antibodies (Table 1, #5 panel B), and (Table 1, #3 panel D). Size bar A, B = 50 μm; C, D = 100 μm.
Hammond et al. BMC Neuroscience 2010 11:121 doi:10.1186/1471-2202-11-121