Table 2

Comparison of KEGG molecular pathway enrichment for high, medium and low stringency filtered genes.

Low Stringency Set

Genes

%input

P-Value

Benjam


Complement and coagulation cascades

26

1.3

1.3E-08

2.6E-06

Linoleic acid metabolism

15

0.7

1.3E-04

1.3E-02

Metabolism of xenobiotics by cytochrome P450

18

0.9

5.9E-04

3.8E-02

Medium Stringency Set

Genes

%input

P-Value

Benjam

Complement and coagulation cascades

19

3.1

7.4E-12

1.5E-09

Linoleic acid metabolism

15

2.5

1.1E-10

1.1E-08

Metabolism of xenobiotics by cytochrome P450

16

2.6

5.9E-09

3.8E-07

Arachidonic acid metabolism

10

1.7

6.2E-04

3.0E-02

gamma-Hexachlorocyclohexane degradation

6

1

9.1E-04

3.5E-02

High Stingency Set

Genes

%input

P-Value

Benjam

Linoleic acid metabolism

15

2.9

1.2E-11

2.3E-09

Complement and coagulation cascades

16

3.1

7.3E-10

7.1E-08

Metabolism of xenobiotics by cytochrome P450

15

2.9

6.0E-09

3.9E-07

Arachidonic acid metabolism

10

2

1.8E-04

8.9E-03

gamma-Hexachlorocyclohexane degradation

6

1.2

4.3E-04

1.7E-02


Genes heading indicates number of genes mapped to an ontology category. % input indicates the percentage of mapped genes from the total number of genes in the cluster. P-Value derived from Fishers exact test and Benjam indicates P-value after application of Benjamini multiple test correction.

Ryan et al. BMC Neuroscience 2010 11:107   doi:10.1186/1471-2202-11-107

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