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This article is part of the supplement: Eighteenth Annual Computational Neuroscience Meeting: CNS*2009

Open Access Poster presentation

Links between complex spikes and multiple synaptic plasticity mechanisms in the cerebellar cortex

Rodrigo Publio1* and Erik De Schutter12

Author Affiliations

1 Computational Neuroscience Unit, Okinawa Institute of Science and Technology, Okinawa 904-0411, Japan

2 Theoretical Neurobiology, University of Antwerp, B-2610 Antwerpen, Belgium

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BMC Neuroscience 2009, 10(Suppl 1):P326  doi:10.1186/1471-2202-10-S1-P326

The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1471-2202/10/S1/P326


Published:13 July 2009

© 2009 Publio and De Schutter; licensee BioMed Central Ltd.

Introduction

In the classic cerebellar learning theory the climbing fiber (CF) is activated when the movement is inaccurate and this activation leads changes in the synaptic strength and in the Purkinje cell (PC) output [1,2]. Stimulation of a single CF activates hundreds of synaptic contacts across PC dendrites and triggers a high frequency burst of spikes called complex spike (CS) [3]. However, it is still unclear how changes in the complex spike probability and the time interval between the parallel fiber (PF) and CF inputs will affect the PC single spike response and learning, considering multiple plasticity mechanisms present at PF and CF synapses [4]. In this work, we used a computational model for synaptic transmission to simulate both long-term and short-term plasticity [5,6] and a single compartmental model of the PC [7] to investigate the links between CS probability, multiple plasticity mechanisms and changes in the PC output. The computational model includes the post-synaptic expression of long-term depression between CF and PC [8], long-term potentiation and depression between PF and PC [5] and short-term facilitation between PF and PC [6]. The models were based in previous models for synaptic transmission and were validated according to the available experimental data (Figure 1).

thumbnailFigure 1. Periodic stimuli induced short-term facilitation (A) and paired pulse facilitation (PPF) at PF-PC synapse (B). The solid lines represent the model results for the parameter set that best fit the experimental data [6,9].

References

  1. Marr D: Theory of cerebellar cortex.

    J Physiol (London) 1969, 202:437-455. OpenURL

  2. Albus JS: A Theory of cerebellar function.

    Math Biosci 1971, 10:25-61. Publisher Full Text OpenURL

  3. Jenny TD, Beverley AC, Hausser M: The origin of the complex spike.

    J Neurosci 2008, 28:7599-7609. PubMed Abstract | Publisher Full Text OpenURL

  4. Hansel C, Linden DJ, D'Angelo E: Beyond parallel fiber LTD: the diversity of synaptic and non-synaptic plasticity in the cerebellum.

    Nat Neurosci 2001, 4:467-475. PubMed Abstract | Publisher Full Text OpenURL

  5. Coesmans M, Weber JT, De Zeeuw CI, Hansel C: Bidirectional parallel fiber plasticity in the cerebellum under climbing fiber control.

    Neuron 2004, 44:691-700. PubMed Abstract | Publisher Full Text OpenURL

  6. Goto JI, Inoue T, Kuruma A, Mikoshiba K: Short-term potentiation at the parallel fiber-Purkinje cell synapse.

    Neurosci Res 2006, 55:28-33. PubMed Abstract | Publisher Full Text OpenURL

  7. Akemann W, Knopfel T: Interaction of Kv3 potassium channels and resurgent sodium current influences the rate of spontaneous firing of Purkinje neurons.

    J Neurosci 2006, 26:4602-4612. PubMed Abstract | Publisher Full Text OpenURL

  8. Hansel C, Linden DJ: Long-term depression of the cerebellar climbing fiber-Purkinje neuron synapse.

    Neuron 2000, 26:473-482. PubMed Abstract | Publisher Full Text OpenURL

  9. Empson RM, Garside ML, Knöpfel T: Plasma membrane Ca2+ ATPase 2 contributes to short-term synapse plasticity at the parallel fiber to purkinje neuron synapse.

    J Neurosci 2008, 27:3753-3758. Publisher Full Text OpenURL